Clinical Need

The tricuspid valve is one of four heart valves that is essential to maintain a unidirectional flow of blood through the heart, allowing it to efficiently pump blood throughout the body. Frequently, especially among the elderly, the tricuspid valve can start to fail and lead to a condition known as tricuspid regurgitation (TR) where blood flows backwards during the heart’s contraction. Depending on the severity of the backflow, individuals may experience symptoms such as fatigue, weakness, abdominal swelling, and palpitations. If TR becomes severe, it may be life threatening and require surgical intervention.

 

Tricuspid Valve Regurgitation (TR) Facts

  • >1.6 million elderly US patients diagnosed with moderate / severe TR

  • Moderate TR can progress and lead to serious symptoms, hospitalizations, and Heart Failure

  • Drug treatment cannot reverse TR and surgery may not be an option due to high risk

  • Consequently, treatment rates for severe symptomatic TR are very low

  • Patients need a better option